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Hyperhomocysteinemia, or high concentrations of homocysteine in the blood, can result in endothelial inflammation
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Some pro-inflammatory cytokines (such as TNF-α, IL-1β, IL-6, and IL-34) can activate a variety of signal transduction pathways, including NF-κB, MAPK, JAK/STAT and PI3K/Akt pathways
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