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Conversely, patients who begin immunotherapy while receiving corticosteroids (for example, in the treatment of brain metastases) appear to have worse outcomes 10
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Parkinsonism associated deglycase, also known as DJ-1, a mitochondrial ROS scavenging protein where mutations cause an autosomal recessive form of PD, suppresses ferroptosis by preserving transsulfuration-mediated GSH synthesis, where its reduction results in increased lipid peroxidation that may contribute to neurodegeneration [542]
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