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Microglia releases cytotoxic mediators such as IL-1β, IL-6 and TNFα, causing pro-inflammatory reactions, however, anti-inflammatory cytokines such as IL-4, IL-13 and Arg-1 are also secreted in microglia activation
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The MMP-2 and MMP-9 have a typical structure that comprises three main domains: the propeptide, the catalytic site with zinc ion, and a hemopexin domain, linked to a fibronectin type II-rich sequence, that confers specificity and high affinity for proteolyzing gelatin and type IV collagen in the basement membrane
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