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In a mouse model of bilateral common carotid artery stenosis (BCAS), which induces chronic cerebral hypoperfusion and inflammation that contribute to cognitive impairment, a 16:8 TRF diet (i.e., 16 h fasting/8 h eating window) led to significantly lower NLRP3, absent in melanoma 2 (AIM2), caspase-8, and precursor IL-1β in brain tissue at 30 days post-surgery compared to ad libitum-fed BCAS mice 19
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