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The site of trauma and supervening inflammation are localized by increasingly severe astrocytic reaction that not only walls off the site but also appears to actively transfer edema fluid from surrounding CNS tissue thus contributing to the formation of the COI [2]

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The MBP tag presents high affinity towards amylose, a maltose analogue, with a similar dissociation constant (10 − 6 M) which is often employed as the competitive elution agent (Kellermann and Ferenci, 1982, Miller et al., 1983)