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91,184 These naturally occurring agents, usually contained in the Mediterranean diet, 152 exhibit anti-inflammatory effects by general antioxidant activities directly working on decreasing many risk factors, including oxidized DNAs, lipid peroxides, and proteins, in AD and other neurodegenerative diseases

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Activated caspase-12 can further shear caspase-3, eventually inducing apoptosis (Figure 4).98 Curcumol Curcumol (Figure 2) is a dominating constituent isolated from the root of the herbal plant turmeric.120 Curcumol possesses significant pharmacological activities such as anti-cancer,121 anti-inflammatory,122 and anti-fibrotic.123 Wang et al investigated that curcumol inhibited the progression of endometriosis by inhibiting the JAK2/STAT3 pathway in vivo and in vitro.124 JAK2/STAT3 is an important signaling axis in the cell proliferation, apoptosis, and inflammation