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Description From Genova’s Website “Personalized Results Overview and Nutrient Need Overview Functional Imbalance Scores in areas of methylation, toxic exposure, mitochondrial dysfunction, fatty acid imbalances, and oxidative stress Nutrient Need Overview with recommendations for antioxidants, B-vitamins, minerals, essential fatty acids, GI support, and amino acids Interpretation-At-A-Glance pages provide nutritional educational support for you and your patient highlighting the function of each nutrient, cause of deficiency, complications of deficiency and food sources of the nutrient Organic Acids (urine) Malabsorption and Bacterial/ Yeast Dysbiosis Markers are metabolites produced by the gastrointestinal microbiome Cellular Energy & Mitochondrial Metabolites are biomarkers of carbohydrate and fatty acid metabolism, and the citric acid (Kreb’s) cycle Neurotransmitter Metabolites are downstream byproducts of epinephrine, norepinephrine, serotonin and dopamine Vitamin Markers are specific analytes used to assess functional levels of vitamin cofactors Toxin & Detoxification Markers relate to certain toxic metabolites and the body’s detoxification capacity Oxalate Markers relate to kidney stone formation, oxidative stress and metabolic dysfunction Oxidative Stress Markers include antioxidants glutathione (whole blood) and Coenzyme Q10 (serum), as well as the oxidative damage markers lipid peroxides and 8-OHdG (urine) Amino Acids (plasma or urine) Essential Amino Acids must be derived from dietary sources Nonessential Amino Acids are synthesized by the body Intermediary Metabolites are byproducts of amino acid metabolism B Vitamin Markers are involved in biochemical reactions that specifically require B vitamins Urea Cycle Markers are byproducts associated with nitrogen (ammonia) detoxification Glycine/Serine Metabolites are involved in the serine-to-choline pathway and the methylation pathways Dietary Peptide Related Markers can indicate incomplete protein breakdown and meat intake Essential and Metabolic Fatty Acids Markers (RBCs) Omega 3 Fatty Acids are essential for brain function and cardiovascular health and are anti-inflammatory Omega 6 Fatty Acids are involved in the balance of inflammation Omega 9 Fatty Acids are important for brain growth, nerve cell myelin, and reducing inflammation Saturated Fatty Acids are involved in liproprotein metabolism and adipose tissue inflammation Monounsaturated Fats include omega 7 fats and unhealthy trans fats Delta-6 Desaturase Activity assesses efficiency of this enzyme to metabolize omega 6’s and omega 3’s Cardiovascular Risk includes specific ratios and the Omega 3 Index Elemental Markers Nutrient Elements are direct measurements of copper and zinc (plasma), magnesium and potassium (RBC), and manganese and selenium (whole blood) Toxic Elements (whole blood) indicate exposure to lead, mercury, arsenic or cadmium within approximately a 90-120 day timeframe Add-on Vitamin D (serum) measures a total of 25-hydroxyvitamin D3 (cholecalciferol) and 25-hydroxyvitamin D2 (ergocalciferol) Add-on SNPs (buccal swab) include MTHFR, COMT, TNF-a, and APOE”