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UPF1-HP-E3 mut contains two amino acid substitutions (G495R and G497E) for hyperphosphorylation and three additional amino acid substitutions (S124A, N138A, and T139A) for disrupting a putative E2-binding pocket and accordingly is hyperphosphorylated and lacks its E3 ubiquitin ligase activity 32
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Клиническое исследование, проведенное российскими учеными на базе Тульского областного наркологического диспансера, продемонстрировало эффективность препаратов глутатиона в терапии алкогольной болезни печени как в целом, так и в сравнении с другими гепатопротекторами
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