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Under ERS condition, unfolded protein reaction (UPR) is activated, which mainly activates protein kinase R-like endoplasmic reticulum kinase (PERK) through glucose regulatory protein 78(GRP78)/binding protein (BiP)
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Although, LCDV1-VILP shares ~50% homology with the IGFs of certain species of fish and reptiles, which might suggest horizontal gene transfer, the sequence conservation of LCDV1-VILP is almost as high with human IGFs and insulin (~47%), making this hypothesis uncertain
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